Hutchings D E, Bodnarenko S R, Diaz-DeLeon R
Pharmacol Biochem Behav. 1984 Feb;20(2):251-4. doi: 10.1016/0091-3057(84)90251-x.
Either 5 or 10 mg/kg of phencyclidine hydrochloride (PCP) was administered by gastric intubation to gravid rats during the last two weeks of gestation. Intubation controls received the vehicle and all offspring were fostered to untreated controls at birth. PCP produced a decrement in maternal weight gain and a small but nonsignificant reduction in birth weight that was no longer evident at weaning. There were no maternal deaths nor were resorptions or stillbirths increased by PCP exposure. Offspring were tested for differences in locomotor activity from birth to weaning at 30 days of age and during adulthood. No behavioral differences were found among the preweanling or adult offspring. Results are compared with other prenatal studies of PCP toxicity and teratogenicity.
在妊娠的最后两周，通过胃管向妊娠大鼠给予5或10毫克/千克的盐酸苯环己哌啶（PCP）。插管对照组接受赋形剂，所有后代在出生时被寄养给未处理的对照母鼠。PCP导致母鼠体重增加减少，出生体重有轻微但不显著的降低，这种降低在断奶时不再明显。PCP暴露未导致母鼠死亡，也未增加吸收胎或死产。对后代从出生到30日龄断奶以及成年期的运动活动差异进行了测试。在断奶前或成年后代中未发现行为差异。将结果与其他关于PCP毒性和致畸性的产前研究进行了比较。
