Fico T A, Banks A N, Hutchings D E
New York State Psychiatric Institute, Department of Developmental Psychobiology, NY 10032.
Pharmacol Biochem Behav. 1990 Jan;35(1):93-7. doi: 10.1016/0091-3057(90)90210-9.
Either 5 or 10 mg/kg of phencyclidine (PCP) in saline was administered by subcutaneous injection to gravid dams during the last two weeks of gestation. A pair-fed control group was administered the vehicle alone and allowed to eat and drink only the amount consumed by the 10 mg/kg group on the same gestation days. A nontreated control group was left undisturbed during pregnancy. All treated and control litters were fostered at birth to untreated dams. Among the dams receiving 10 mg/kg of PCP, food and water intake was initially reduced to 33-43% of nontreated controls, but then returned to control levels. Surprisingly, after 3 days of drug administration, water intake of PCP-treated dams exceeded that of the nontreated dams by approximately 15%. Compared with the nontreated dams, both PCP groups and pair-fed control dams gained significantly less body weight from conception to term. PCP had no significant effect on number of implantation sites or number of live births, however, PCP produced an apparent selective embryolethal effect on males and body weight reduction in all groups at birth. Prenatal PCP did not alter the sensitivity to apomorphine-induced climbing behavior during the second postnatal week. These results are discussed with respect to published animal and clinical studies of PCP exposure during pregnancy.
在妊娠的最后两周，通过皮下注射向妊娠母鼠给予5或10毫克/千克的苯环己哌啶（PCP）生理盐水溶液。一对喂食对照组仅给予赋形剂，并在相同的妊娠天数内仅允许其进食和饮水10毫克/千克组所消耗的量。一个未处理的对照组在怀孕期间不做任何干预。所有处理组和对照组的幼崽在出生时都寄养给未处理的母鼠。在接受10毫克/千克PCP的母鼠中，食物和水的摄入量最初降至未处理对照组的33%-43%，但随后又恢复到对照水平。令人惊讶的是，在给药3天后，接受PCP处理的母鼠的饮水量比未处理的母鼠高出约15%。与未处理的母鼠相比，PCP组和一对喂食对照母鼠从受孕到足月体重增加都显著较少。PCP对着床部位数量或活产数量没有显著影响，然而，PCP对雄性产生了明显的选择性胚胎致死作用，并使所有组出生时的体重减轻。产前PCP并未改变产后第二周对阿扑吗啡诱导的攀爬行为的敏感性。本文结合已发表的关于孕期接触PCP的动物和临床研究对这些结果进行了讨论。
