Möller P, Bergström J, Fürst P, Hellström K
Scand J Gastroenterol. 1984 Mar;19(2):267-72.
Energy-rich phosphagens, water, and electrolytes were determined in skeletal muscle biopsy specimens from five elderly women and five elderly men with moderate liver cirrhosis. At the time of the study the patients were in their usual condition without evidence of deterioration of the disease. When compared with findings in apparently healthy subjects of similar age, the distribution and level of electrolytes and water were within normal limits in the female patients. The male patients showed increased contents of muscle water, and Mg2+ was reduced. The values calculated for the intracellular concentration of K+ and Mg2+ were also below normal. The pattern and levels of energy-rich phosphagens were abnormal in all but one female patient. As a general finding, ATP and the total level of adenine nucleotides were markedly reduced, as were phosphocreatine, the ATP/ADP ratio, and the energy charge potential.
对五名患有中度肝硬化的老年女性和五名老年男性的骨骼肌活检标本进行了富含能量的磷酸原、水和电解质的测定。在研究时，患者处于其通常状态，无疾病恶化迹象。与年龄相仿的明显健康受试者的检查结果相比，女性患者的电解质和水的分布及水平在正常范围内。男性患者的肌肉含水量增加，镁离子含量降低。计算得出的细胞内钾离子和镁离子浓度值也低于正常水平。除一名女性患者外，所有患者的富含能量的磷酸原的模式和水平均异常。总的来说，三磷酸腺苷（ATP）和腺嘌呤核苷酸的总水平显著降低，磷酸肌酸、ATP/二磷酸腺苷（ADP）比值以及能量电荷势也降低。
