Flores M, Agosti J, Damborenea C, Aguirre C
Scand J Rheumatol. 1984;13(1):28-32. doi: 10.3109/03009748409102664.
The valvular lesions caused by rheumatoid arthritis have been known for a long time. The valves may be affected by unspecific inflammatory changes or, specifically, by rheumatoid granulomas identical with subcutaneous nodules that lead to the malfunctioning of the aortic or the mitral valve. We present a patient affected by a classical seropositive rheumatoid arthritis accompanied by a severe aortic insufficiency and a prolapse of the mitral valve with rheumatoid involvement of the histologic granulomatous type, in whom both valves were replaced in two phases. The hemodynamic results were good for a period of time. Replacement of the valve by a prosthesis is the ideal treatment. There is no experience with treatment such a medication with immunosuppressive drugs.
类风湿关节炎引起的瓣膜病变早已为人所知。瓣膜可能受到非特异性炎症改变的影响，或者具体来说，受到与皮下结节相同的类风湿肉芽肿的影响，从而导致主动脉瓣或二尖瓣功能失常。我们报告一例患有典型血清阳性类风湿关节炎的患者，伴有严重的主动脉瓣关闭不全和二尖瓣脱垂，且存在组织学肉芽肿型类风湿累及，该患者分两个阶段进行了双瓣膜置换。一段时间内血流动力学结果良好。用人工瓣膜置换瓣膜是理想的治疗方法。目前尚无使用免疫抑制药物治疗此类疾病的经验。
