Ansari R A, Siddiqui M K, Gupta P K
Toxicol Lett. 1984 Apr;21(1):29-33. doi: 10.1016/0378-4274(84)90219-4.
Endosulfan was administered orally (2.5 and 7.5 mg/kg) daily to male rats for a period of 60 days. The distribution pattern of alpha and beta-isomers was studied using a gas-liquid chromatograph equipped with an electron capture detector. There was a significant increase in liver and lung weights. The testes weight was slightly decreased. No significant change in weights of other tissues was observed. At both dose levels, the concentration of alpha-isomer was highest in kidney (574 and 1655 ng/g, respectively), followed by lung, ventral prostate, spleen, testes and brain. In the seminal vesicle, epididymis, heart and liver, the concentration of beta-isomer was higher than the alpha-isomer. The results of the study indicated a differential ability to accumulate the two isomers of endosulfan which may help to explain the difference in the toxic potential of the alpha- and beta-isomers.
将硫丹以2.5毫克/千克和7.5毫克/千克的剂量每日口服给予雄性大鼠，持续60天。使用配备电子捕获检测器的气液色谱仪研究了α-和β-异构体的分布模式。肝脏和肺的重量显著增加。睾丸重量略有下降。未观察到其他组织重量有显著变化。在两个剂量水平下，α-异构体在肾脏中的浓度最高（分别为574纳克/克和1655纳克/克），其次是肺、腹侧前列腺、脾脏、睾丸和大脑。在精囊、附睾、心脏和肝脏中，β-异构体的浓度高于α-异构体。研究结果表明硫丹的两种异构体具有不同的蓄积能力，这可能有助于解释α-和β-异构体毒性潜力的差异。
