Gupta P K, Gupta R C
Toxicology. 1977 Jun;7(3):283-8. doi: 10.1016/0300-483x(77)90048-8.
The effects of endosulfan on the weights of the liver, adrenal and ovary, on pentobarbital blood and brain levels and on sleeping time (ST) have been investigated in female rats after daily oral doses of 0, 1.0, 2.5 and 5.0 mg/kg for a period of 7 or 15 days. No significant change in body weight was observed. With higher doses (2.5--5.0 mg/kg) the liver weight was significantly increased, but ovary and adrenal weights did not increase. Endosulfan treatment shortened sleeping time, while induction time was significantly increased. The concentration of pentobarbital in the blood and brain of rats after 30 min and upon awakening indicated that there was a significant decrease at 30 min. No change at awakening was observed in endosulfan-treated rats as compared to controls. It is suggested tha endosulfan may shorten the duration of pentobarbital-induced sleep, perhaps by induction of hepatic microsomal enzyme activity.
对雌性大鼠每日经口给予0、1.0、2.5和5.0毫克/千克硫丹，持续7天或15天，研究了硫丹对肝脏、肾上腺和卵巢重量、戊巴比妥血药浓度和脑药浓度以及睡眠时间（ST）的影响。未观察到体重有显著变化。较高剂量（2.5 - 5.0毫克/千克）时肝脏重量显著增加，但卵巢和肾上腺重量未增加。硫丹处理缩短了睡眠时间，而诱导时间显著延长。给药30分钟及苏醒时大鼠血液和脑中戊巴比妥的浓度表明，30分钟时显著降低。与对照组相比，硫丹处理的大鼠苏醒时未观察到变化。提示硫丹可能通过诱导肝微粒体酶活性缩短戊巴比妥诱导的睡眠时间。
