醋酸铅对听力影响的实验研究。豚鼠的耳蜗微音器电位和动作电位。

An experimental study of the effects of lead acetate on hearing. Cochlear microphonics and action potential of the guinea pig.

作者信息

Yamamura K, Kishi R, Maehara N, Sadamoto T, Uchino E

出版信息

Toxicol Lett. 1984 Apr;21(1):41-7. doi: 10.1016/0378-4274(84)90221-2.

PMID:6719486

Abstract

Guinea pigs were poisoned with repeated i.p. injections of 1% lead acetate. After 5 weeks, the animals were examined electrophysiologically by using cochlear microphonics (CM) and action potential (AP). The thresholds of maximum voltage of N1 in the AP of the animals injected with a total of 100 mg lead acetate were elevated about 15 dB and increased N1 latency was also observed. However, no significant changes in those of CM were found. The results suggest that lead acetate not only induces damage to the peripheral nerves, but also to the cranial nerves.

摘要

豚鼠通过腹腔内反复注射1%醋酸铅中毒。5周后，通过使用耳蜗微音器电位（CM）和动作电位（AP）对动物进行电生理学检查。总共注射100mg醋酸铅的动物的AP中N1的最大电压阈值升高了约15dB，并且还观察到N1潜伏期增加。然而，CM的这些参数没有发现显著变化。结果表明，醋酸铅不仅会导致外周神经损伤，还会导致颅神经损伤。