福斯可林对豚鼠耳蜗声诱发电位的影响。

The effect of forskolin on the sound-evoked potentials in the guinea pig cochlea.

作者信息

Kitano I, Mori N, Nario K, Doi K, Matsunaga T

机构信息

Department of Otolaryngology, Nara Medical University, Kashihara City, Japan.

出版信息

Acta Otolaryngol Suppl. 1998;533:4-8. doi: 10.1080/00016489850183647.

DOI:10.1080/00016489850183647

PMID:9657301

Abstract

The effect of forskolin (FSK) on cochlear sound-evoked potentials was examined in the guinea pig. The perfusion of the scala vestibuli (SV) with FSK (2 x 10(-4) M) produced a significant increase in the amplitude of negative summating potential (- SP) with no change in cochlear microphonics (CM) amplitude, and a significant decrease in the amplitude of compound action potential (CAP) with a significant prolongation of N1 latency and a 20 dB CAP threshold elevation. The results lead us to speculate that FSK-induced changes may be involved in the transient formation of endolymphatic hydrops.

摘要

在豚鼠身上研究了福斯高林（FSK）对耳蜗声诱发电位的影响。用FSK（2×10⁻⁴ M）灌注前庭阶（SV），负和电位（-SP）的幅度显著增加，而耳蜗微音器电位（CM）的幅度无变化，复合动作电位（CAP）的幅度显著降低，N1潜伏期显著延长，CAP阈值升高20 dB。这些结果使我们推测，FSK诱导的变化可能与内淋巴积水的短暂形成有关。