苯甲基磺酰氟对四氯化碳诱导的肝坏死的晚期预防作用。

Late preventive effects of phenylmethylsulfonyl-fluoride on carbon tetrachloride-induced liver necrosis.

作者信息

de Ferreyra E C, de Fenos O M, Castro J A

出版信息

Toxicol Lett. 1984 May;21(2):173-8. doi: 10.1016/0378-4274(84)90202-9.

PMID:6719499

Abstract

The administration to rats of phenylmethylsulfonylfluoride (PMSF) 6 or 10 h after tetrachloride (CCl4) significantly prevented liver necrosis induced by this hepatotoxin at 24 h but not at 72 h. Preventive effects of PMSF were not due to interference with CCl4 absorption from the peritoneum since CCl4 levels in livers of treated and untreated animals were not significantly different. The present and previous results from our laboratory suggest that degradative processes mediated by proteases and esterases might play a role in late reversible stages of CCl4-induced liver cell injury.

摘要

在给大鼠注射四氯化碳（CCl4）后6或10小时给予苯甲基磺酰氟（PMSF），可显著预防该肝毒素在24小时时诱导的肝坏死，但在72小时时则不能预防。PMSF的预防作用并非由于干扰了CCl4从腹膜的吸收，因为经处理和未处理动物肝脏中的CCl4水平并无显著差异。我们实验室目前和之前的结果表明，由蛋白酶和酯酶介导的降解过程可能在CCl4诱导的肝细胞损伤的晚期可逆阶段发挥作用。