某些自主神经药物对离体犬输尿管自发收缩的作用。

Actions of some autonomic drugs on spontaneous contractions of isolated dog ureter.

作者信息

Yano S, Ueda S, Ikegami K, Mutoh S, Sakanashi M

出版信息

Urol Int. 1984;39(2):100-4. doi: 10.1159/000280954.

PMID:6719633

Abstract

Effects of some autonomic drugs on the isolated dog ureteral preparations showing spontaneous contractions were investigated quantitatively. Noradrenaline, adrenaline and phenylephrine produced increases in frequency and tension of the contractions which were reversed to decreases or depressed by phentolamine. Isoproterenol abolished the spontaneous contractions. Acetylcholine did not significantly change frequency and tension of the contractions. The results indicate that ureteral spontaneous contractions may be enhanced through an activation of alpha-adrenoceptors and be attenuated through an activation of beta-adrenoceptors. However, acetylcholine will not display an important role on the ureteral contractions.

摘要

对一些能使离体犬输尿管制剂产生自发收缩的自主神经药物的作用进行了定量研究。去甲肾上腺素、肾上腺素和去氧肾上腺素可使收缩频率和张力增加，而酚妥拉明可使其逆转至降低或抑制。异丙肾上腺素可消除自发收缩。乙酰胆碱对收缩频率和张力无明显影响。结果表明，输尿管自发收缩可能通过α -肾上腺素能受体的激活而增强，通过β -肾上腺素能受体的激活而减弱。然而，乙酰胆碱在输尿管收缩中不起重要作用。