Siering H, Przesang R
Z Gesamte Inn Med. 1984 Mar 1;39(5):81-4.
In the bone marrow of guinea pigs a decrease of lymphocytes resulted after immunisation against Q-fever antigen, compensating within 4 weeks. Under treatment with prednisolone normalisation occurred within 3, with aristolochic acid as well as with prednisolone and aristolochic acid already up to the 2nd week. After immunisation plasma cell increase was lasting longer in the aristolochic acid group than in other groups. The antibody determinations resulted in different values. After immunisation with Q-fever antigen the antibody levels in rabbits increased without significant differences between the control animals and the animals treated with prednisolone or aristolochic acid. An special increase of antibody formation was to be observed in the group with combined therapy. Possibilities for the influence on the immune response by the drugs used are discussed.
在豚鼠的骨髓中，用Q热抗原免疫后淋巴细胞数量减少，4周内得到补偿。在用泼尼松龙治疗的情况下，3周内恢复正常，使用马兜铃酸以及泼尼松龙和马兜铃酸联合治疗时，在第2周就已恢复正常。免疫后，马兜铃酸组浆细胞增加持续的时间比其他组更长。抗体测定结果显示出不同的值。用Q热抗原免疫后，兔子体内抗体水平升高，对照组动物与用泼尼松龙或马兜铃酸治疗的动物之间无显著差异。在联合治疗组中观察到抗体形成有特殊增加。文中讨论了所用药物对免疫反应的影响可能性。
