Siering H, Müller H J
Arzneimittelforschung. 1981;31(8):1260-2.
The influence of prednisolone and 3,4-methylenedioxy-8-methoxy-10-nitrophenanthrenecarbonic acid-1 (aristolochic acid) on the immunocyte adherence phenomenon in the rat was investigated. The following results were obtained: Prednisolone diminishes the number of rosettes. Aristolochic acid itself has no influence on the number of rosettes but compensates the diminuation caused by prednisolone. Equal effects were found for 5 mg/kg b.w. prednisolone and 0.005 mg/kg aristolochic acid. This effect of aristolochic acid is interpreted as competitive inhibition of surface receptors of lymphocytes.
研究了泼尼松龙和3,4-亚甲二氧基-8-甲氧基-10-硝基菲甲酸-1（马兜铃酸）对大鼠免疫细胞黏附现象的影响。得到以下结果：泼尼松龙减少玫瑰花结数量。马兜铃酸本身对玫瑰花结数量没有影响，但能补偿泼尼松龙引起的减少。5mg/kg体重的泼尼松龙和0.005mg/kg的马兜铃酸具有相同的效果。马兜铃酸的这种作用被解释为对淋巴细胞表面受体的竞争性抑制。
