Postnov Iu V, Orlov S N, Pokudin N I
Kardiologiia. 1978 Jun;18(6):107-11.
Under conditions of physiological concentration of free calcium in the incubation medium (Ca2+f = 1.5 mM), the outer surface of the membrane of human and Wistar rat erythrocytes binds 435 +/- and 359 +/- 32 nmol calcium per 1 ml cells, respectively. The external surface of erythrocytes in patients with essential hypertension and in rats with spontaneous hypertension (SHR, Kyoto Wistar) also binds such amounts of calcium. With the concentration of calcium corresponding to its concentration in the intracellular space (Ca2+f less than 1 mcM), the inner membrane surface of eritrocyte ghosts binds only 3.53 +/- 0.16 and 4.28 +/- 0.39 nmol calcium per 1 mg protein of human and rat eritrocyte ghosts, respectively. The noted decrease in the calcium-binding capacity of the inner part of the erythrocyte membrane, being probably a characteristic feature of membrane alteration displayed also in other cellular structure, may determine the changes in tissue sensitivity to the effect of hormones and catecholamines in both types of hypertension.
在孵育介质中游离钙处于生理浓度（Ca2+f = 1.5 mM）的条件下，人红细胞和Wistar大鼠红细胞膜的外表面每1 ml细胞分别结合435±和359±32 nmol钙。原发性高血压患者和自发性高血压大鼠（京都Wistar SHR）红细胞的外表面也结合等量的钙。当钙浓度与其在细胞内空间的浓度相对应时（Ca2+f小于1 μM），人红细胞膜空壳和大鼠红细胞膜空壳的内膜表面每1 mg蛋白质分别仅结合3.53±0.16和4.28±0.39 nmol钙。红细胞膜内部钙结合能力的上述降低可能是膜改变的一个特征，这种改变也在其他细胞结构中表现出来，可能决定了两种类型高血压中组织对激素和儿茶酚胺作用的敏感性变化。
