Zhao G
Shanghai Institute of Hypertension, Shanghai Second Medical University.
Zhonghua Xin Xue Guan Bing Za Zhi. 1990 Oct;18(5):258-9, 318.
Several abnormalities of calcium transport have been reported in human essential hypertension (EHT) and spontaneous hypertensive rat (SHR). 45Ca binding capacity to erythrocyte membrane was measured in this study by filtration technique in the presence of 80 nmol/L Ca concentration. Results showed: (1) It was much lower in EHT (33 cases) than normal control (19 men) group, being 0.22 +/- 0.13 versus 0.35 +/- 0.18 nmol Ca2+/mg membrane protein (P less than 0.01), and correlated positively with blood pressure levels. (2) The average Ca binding capacity in young offsprings (15 adolescents) with both parents hypertensive was lower, but statistically not significant. (3) The average Ca binding capacity was also lower in SHR (9 rats) than control WKY (10 rats) group, being 0.83 +/- 0.27 versus 0.98 +/- 0.24 nmol Ca2+/mg membrane protein, yet statistically not significant. Therefore a decrement of membrane binding capacity might be related to the occurrence and maintenance of hypertension.
在人类原发性高血压（EHT）和自发性高血压大鼠（SHR）中，已有多项钙转运异常的报道。本研究采用过滤技术，在80 nmol/L钙浓度下测定红细胞膜的45Ca结合能力。结果显示：（1）EHT组（33例）的该能力显著低于正常对照组（19名男性），分别为0.22±0.13与0.35±0.18 nmol Ca2+/mg膜蛋白（P<0.01），且与血压水平呈正相关。（2）双亲均患高血压的年轻后代（15名青少年）的平均钙结合能力较低，但无统计学意义。（3）SHR组（9只大鼠）的平均钙结合能力也低于对照WKY组（10只大鼠），分别为0.83±0.27与0.98±0.24 nmol Ca2+/mg膜蛋白，同样无统计学意义。因此，膜结合能力的降低可能与高血压的发生和维持有关。
