Danielsson B R, Bergman K, d'Argy R
Acta Pharmacol Toxicol (Copenh). 1984 Mar;54(3):233-40. doi: 10.1111/j.1600-0773.1984.tb01923.x.
Occupational exposure to carbon disulfide (CS2) has been associated with an increased rate of spontaneous abortions. Animal experiments have shown that CS2 is embryotoxic and teratogenic. In the present study, the embryonal and foetal distribution of CS2 and its metabolites was studied after administration of 35S- or 14C-labelled CS2 to pregnant mice in different stages of gestation. CS2 and its metabolites passed the placenta at all stages of gestation. High levels of metabolites of CS2 were registered in the embryonic neuroepithelium. In mid and late gestation CS2 itself accumulated in the cerebrospinal fluid (CSF) of the brain. 14C-labelled metabolites of CS2 showed affinity for bone and were retained in the liver even at long survival times (24 hours). These localizations may be of significance for some of the reported teratogenic effects of CS2, such as hydrocephalus, ossification defects and foetal liver injury, and support the idea that CS2 and/or its metabolites are embryotoxic and teratogenic by acting directly on embryonal and foetal structures.
职业性接触二硫化碳（CS2）与自然流产率升高有关。动物实验表明，CS2具有胚胎毒性和致畸性。在本研究中，给处于不同妊娠阶段的怀孕小鼠注射35S或14C标记的CS2后，研究了CS2及其代谢产物在胚胎和胎儿体内的分布情况。在妊娠的各个阶段，CS2及其代谢产物均可通过胎盘。在胚胎神经上皮中检测到高水平的CS2代谢产物。在妊娠中期和晚期，CS2本身在脑脊髓液（CSF）中蓄积。14C标记的CS2代谢产物对骨骼具有亲和力，即使在较长存活时间（24小时）时仍保留在肝脏中。这些分布情况可能与CS2所报告的一些致畸作用有关，如脑积水、骨化缺陷和胎儿肝损伤，并支持CS2和/或其代谢产物通过直接作用于胚胎和胎儿结构而具有胚胎毒性和致畸性这一观点。
