Bergman K, Danielsson B R, d'Argy R
Acta Pharmacol Toxicol (Copenh). 1984 Feb;54(2):141-50. doi: 10.1111/j.1600-0773.1984.tb01908.x.
Occupational exposure to carbon disulfide (CS2) is associated with several adverse effects such as neurotoxicity, atherosclerosis, liver injury and endocrinal disturbances. In the present study, the distribution of CS2 and its metabolites after inhalation of 35S- or 14C-labelled CS2 was studied in adult male mice with whole-body autoradiography. CS2 itself was registered in body fat and in well-perfused tissues at survival times up to 2 hours. Very little CS2 was taken up by the brain. The distribution patterns of CS2 metabolites were very different after administration of C35S2 or 14CS2. 35S-Labelled metabolites were initially concentrated in the liver and kidney, but were rapidly eliminated from the body. There was evidence of an extensive metabolic incorporation of sulfur split off from CS2 during its biotransformation. 14C-Labelled metabolites were likewise concentrated in the liver and kidney, but were also observed in large amounts in the nasal mucosa, bronchi, bone, pancreas, thyroid, adrenal cortex and testis. A marked retention of non-extractable 14C-labelled metabolites was seen in the liver and thyroid. The results point to several sites of specific CS2-induced toxicity due to the tissue disposition of metabolites of CS2.
职业性接触二硫化碳（CS2）与多种不良反应有关，如神经毒性、动脉粥样硬化、肝损伤和内分泌紊乱。在本研究中，通过全身放射自显影技术，对成年雄性小鼠吸入35S或14C标记的CS2后CS2及其代谢产物的分布进行了研究。在长达2小时的存活时间内，CS2本身在体脂和灌注良好的组织中被检测到。脑摄取的CS2很少。给予C35S2或14CS2后，CS2代谢产物的分布模式有很大差异。35S标记的代谢产物最初集中在肝脏和肾脏，但很快从体内消除。有证据表明，在CS2生物转化过程中，从CS2中分解出的硫发生了广泛的代谢掺入。14C标记的代谢产物同样集中在肝脏和肾脏，但在鼻黏膜、支气管、骨骼、胰腺、甲状腺、肾上腺皮质和睾丸中也大量存在。在肝脏和甲状腺中观察到大量不可提取的14C标记代谢产物的滞留。结果表明，由于CS2代谢产物的组织分布，CS2在几个特定部位可导致毒性。
