Am J Epidemiol. 1984 May;119(5):796-805.
A population of female civil servants in Rome, Italy, was investigated to determine the prevalence of symptomatic and asymptomatic gallstone disease and to define the associated factors. Field activities started in February 1981 and concluded in April 1982. Diagnosis was assessed by real time ultrasonography. Prevalence of gallstone disease increased with age from 2.5% in the 20- to 29-year-old age group to 25.0% in the 60- to 64-year-old age group, based on both presence of gallstones and history of cholecystectomy. Only one third of the women with gallstones had complained of at least one episode of biliary pain in the last five years. Frequency of "minor" dyspeptic symptoms was not different between women with and those without gallstones. In a multiple logistic function analysis, a positive association was found between age, body mass index, parity, and prevalence of gallstone disease. No association was demonstrated between the presence of gallstones or cholecystectomy and other major sex-specific factors, including age at menopause, use of oral contraceptives, and duration and frequency of menstrual cycle.
对意大利罗马的一群女性公务员进行了调查，以确定有症状和无症状胆结石疾病的患病率，并确定相关因素。实地调查活动于1981年2月开始，1982年4月结束。通过实时超声检查进行诊断。根据胆结石的存在情况和胆囊切除术史，胆结石疾病的患病率随年龄增长而增加，从20至29岁年龄组的2.5%增至60至64岁年龄组的25.0%。在过去五年中，只有三分之一有胆结石的女性曾诉说至少有一次胆绞痛发作。有胆结石和无胆结石的女性之间“轻微”消化不良症状的频率没有差异。在多元逻辑函数分析中，发现年龄、体重指数、产次与胆结石疾病患病率之间存在正相关。未证明胆结石或胆囊切除术的存在与其他主要的性别特异性因素之间存在关联，这些因素包括绝经年龄、口服避孕药的使用以及月经周期的持续时间和频率。
