Department of Clinical, Internal, Anaesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00161 Rome, Italy.
Int J Environ Res Public Health. 2021 Feb 18;18(4):1958. doi: 10.3390/ijerph18041958.
Metabolic syndrome (MetS) and gallstone disease (GD) share common risk factors. Several epidemiological studies reported that subjects with Mets are more likely to have GD than those without and that cholecystectomy (CHO) may increase the risk of MetS. The aim of the study was to evaluate the association between MetS and GD in a large cohort of patients with metabolic risk factors in Italy. The study was performed in 620 consecutive outpatients referring to the University outpatients' clinic for the management of cardiovascular risk factors. MetS were diagnosed according to the ATPIII Expert Panel modified criteria. GD was defined as gallstones documented by abdominal ultrasound (US) or previous cholecystectomy. The prevalence of GD was significantly higher in women than in men (22.3% vs. 13.1%, = 0.003). Both prevalence of GD (17.1% vs. 8.4%, = 0.015) and CHO (9.0% vs. 1.7%, = 0.002) were significantly higher in males with MetS as compared to those without. By contrast, the prevalence of GD and of CHO was similar in women with and without MetS. After correction for confounders, MetS was an independent predictor of both GD (odds ratio (OR) 1.943, = 0.048) and CHO (OR 5.075, = 0.011) in men, but not in women. In conclusion, in this study, including western subjects with cardiometabolic risk factors, the association between GD, prior CHO and MetS were found in men, but not in women.
代谢综合征（MetS）和胆石病（GD）有共同的危险因素。一些流行病学研究报告称，患有 Mets 的患者比没有患有 Mets 的患者更容易患有 GD，并且胆囊切除术（CHO）可能会增加 MetS 的风险。本研究旨在评估意大利一组患有代谢危险因素的患者中 MetS 与 GD 之间的关联。该研究在 620 名连续就诊于大学门诊的代谢危险因素患者中进行。MetS 根据 ATPIII 专家小组修改的标准进行诊断。GD 通过腹部超声（US）或先前的胆囊切除术诊断为胆石症。GD 在女性中的患病率明显高于男性（22.3%比 13.1%， = 0.003）。MetS 男性的 GD 患病率（17.1%比 8.4%， = 0.015）和 CHO（9.0%比 1.7%， = 0.002）均明显高于没有 MetS 的男性。相比之下，有或没有 MetS 的女性中 GD 和 CHO 的患病率相似。在调整混杂因素后，MetS 是男性 GD（比值比（OR）1.943， = 0.048）和 CHO（OR 5.075， = 0.011）的独立预测因素，但不是女性的预测因素。总之，在这项研究中，包括有心脏代谢危险因素的西方人群，在男性中发现了 GD、先前的 CHO 和 MetS 之间的关联，但在女性中没有发现。
