Germain M J, Davidman M
Am J Kidney Dis. 1984 May;3(6):420-4. doi: 10.1016/s0272-6386(84)80004-9.
Mixed connective tissue disease (MCTD) is considered to have a benign clinical course. Recently, renal disease has been recognized as a frequent complication (20%). This report describes a patient with MCTD who developed pulmonary hemorrhage and acute renal failure. The renal biopsy, in addition to a long-standing membranous nephropathy, revealed a tubulointerstitial nephritis. Immunofluorescent and electron microscopy showed immune complex deposition along the tubular basement membrane. Life-threatening, immune complex-mediated events can occur in the course of MCTD, manifested as pulmonary hemorrhage and tubulointerstitial nephritis.
混合性结缔组织病（MCTD）被认为临床病程呈良性。近来，肾脏疾病已被公认为常见并发症（20%）。本报告描述了一名患有MCTD的患者，该患者出现了肺出血和急性肾衰竭。肾活检除显示存在长期的膜性肾病外，还发现了肾小管间质性肾炎。免疫荧光和电子显微镜检查显示免疫复合物沿肾小管基底膜沉积。在MCTD病程中可发生危及生命的免疫复合物介导事件，表现为肺出血和肾小管间质性肾炎。
