McLeish K R, Smith M R, Gohara A F
Am J Med Sci. 1985 Oct;290(4):152-4. doi: 10.1097/00000441-198510000-00003.
A 60-year-old woman with a diagnosis of poorly differentiated lymphocytic lymphoma presented with nephrotic syndrome. Her clinical picture and serological studies were consistent with the diagnosis of mixed connective tissue disease (MCTD). Renal biopsy demonstrated the changes of membranous nephropathy by light, immunofluorescence and electron microscopy. Treatment with corticosteroids and cyclophosphamide had no effect on the proteinuria, and she demonstrated progression of renal failure. This patient demonstrates that the lymphadenopathy associated with MCTD may be of a separate malignant origin. The treatment of MCTD may not alter the course of renal disease, and renal failure may ensue in patients with MCTD.
一名60岁诊断为低分化淋巴细胞淋巴瘤的女性出现肾病综合征。她的临床表现和血清学检查结果与混合性结缔组织病（MCTD）的诊断相符。肾活检通过光镜、免疫荧光和电镜显示为膜性肾病的改变。使用皮质类固醇和环磷酰胺治疗对蛋白尿无效，且她出现了肾衰竭进展。该患者表明与MCTD相关的淋巴结病可能有独立的恶性起源。MCTD的治疗可能不会改变肾病进程，MCTD患者可能会出现肾衰竭。
