Hafström L, Carlsson G
Am J Surg. 1984 May;147(5):688-91. doi: 10.1016/0002-9610(84)90143-0.
Interruption of the arterial blood supply to the liver has been used clinically for more than 15 years in patients with nonresectable liver tumors. The induced effect of hepatic artery occlusion on blood flow and metabolism has been studied extensively, whereas survival time has hardly been examined. Evidence of prolongation of survival after hepatic artery ligation, although not properly statistically analyzed, has been found in previous series of experimental animals, but the effect has not been established clinically. In this experimental study of rats with adenocarcinoma in the liver, a statistically significant prolongation of survival time was observed for the animals subjected to hepatic artery ligation when compared with untreated control animals. A statistically significant increase in body weight developed in all ligated animals during the experimental period, whereas the untreated control animals showed a statistically significant decrease in body weight.
在患有不可切除性肝肿瘤的患者中，中断肝脏的动脉血液供应在临床上已应用了15年以上。肝动脉闭塞对血流和代谢的诱导作用已得到广泛研究，而生存时间几乎未被研究。尽管之前一系列实验动物的研究未进行适当的统计学分析，但已发现肝动脉结扎后有生存延长的证据，不过该作用在临床上尚未得到证实。在这项对患有肝腺癌大鼠的实验研究中，与未治疗的对照动物相比，接受肝动脉结扎的动物生存时间有统计学意义的延长。在实验期间，所有结扎动物的体重出现统计学意义的增加，而未治疗的对照动物体重出现统计学意义的下降。
