Adelman S, Dinner D S, Goren H, Little J, Nickerson P
Arch Neurol. 1984 May;41(5):509-10. doi: 10.1001/archneur.1984.04050170055017.
Sleep apnea in association with neurologic disease is uncommon, and its documentation with nocturnal polysomnography (PSG) is rare. Two patients with posterior fossa neurologic disease had obstructive and central sleep apnea on PSG. The first was a 40-year-old woman who experienced a respiratory arrest ten days after neurosurgical decompression of a cervical syrinx associated with syringobulbia. Nocturnal PSG demonstrated obstructive sleep apnea. Tracheostomy was performed and a second nocturnal PSG showed no sleep apnea. The second patient was a 76-year-old woman with daytime hypersomnolence, nocturnal choking spells, progressive spastic paraparesis, and left-sided cerebellar tremor. Neurologic evaluation led to the diagnosis of olivopontocerebellar degeneration. Nocturnal PSG showed multiple episodes of central and obstructive apnea. These cases support the hypothesis that central and obstructive sleep apnea can originate from a central mechanism.
与神经系统疾病相关的睡眠呼吸暂停并不常见，通过夜间多导睡眠图（PSG）记录到这种情况的更是罕见。两名患有后颅窝神经系统疾病的患者在PSG检查中出现阻塞性和中枢性睡眠呼吸暂停。第一名患者是一名40岁女性，在对与延髓空洞症相关的颈髓空洞症进行神经外科减压术后十天出现呼吸骤停。夜间PSG显示为阻塞性睡眠呼吸暂停。进行了气管切开术，第二次夜间PSG显示无睡眠呼吸暂停。第二名患者是一名76岁女性，有日间嗜睡、夜间窒息发作、进行性痉挛性截瘫和左侧小脑震颤。神经学评估诊断为橄榄脑桥小脑变性。夜间PSG显示多次中枢性和阻塞性呼吸暂停发作。这些病例支持中枢性和阻塞性睡眠呼吸暂停可能源于中枢机制这一假说。
