Chandra M, Singh B, Soni G L, Ahuja S P
Avian Dis. 1984 Jan-Mar;28(1):1-11.
Three hundred 18-day-old male chicks (Arbor Acre) were divided into five groups of 60 each and given high-protein (42.28%), high-calcium (3.37%), urea-containing (5%), vitamin-A-deficient, or control diets to study the effect of nutritional imbalances on the development of nephritis and related biochemical changes over 15 weeks. The first four diets increased the levels of glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, uric acid, and nonprotein nitrogen in serum. Blood urea was increased by only the urea diet. Hypoglycemia and a decrease in hepatic glucose-6-phosphatase were also observed in chicks fed the first four diets. The vitamin-A-deficient diet resulted in a depletion of vitamin A in the liver and kidneys. These changes were directly correlated with the prolonged feeding of experimental diets and also with the severity of nephritis and degenerative changes in various organs. It was concluded that increasing the intake of nitrogen or calcium in order to increase production may in fact have the opposite effect, leading to degenerative changes in various tissues and to nephritis.
300只18日龄的雄性艾拔益加肉鸡被分为五组，每组60只，分别给予高蛋白（42.28%）、高钙（3.37%）、含尿素（5%）、缺乏维生素A的饲料或对照饲料，以研究营养失衡对15周内肾炎发展及相关生化变化的影响。前四种饲料会使血清中的谷氨酸草酰乙酸转氨酶、谷氨酸丙酮酸转氨酶、尿酸和非蛋白氮水平升高。仅含尿素的饲料会使血尿素升高。在前四种饲料喂养的雏鸡中还观察到低血糖以及肝葡萄糖-6-磷酸酶减少。缺乏维生素A的饲料导致肝脏和肾脏中的维生素A耗竭。这些变化与实验饲料的长期喂养直接相关，也与肾炎的严重程度和各器官的退行性变化相关。得出的结论是，为了提高产量而增加氮或钙的摄入量实际上可能会产生相反的效果，导致各种组织的退行性变化和肾炎。
