Heneghan C P, Bergman N A, Jones J G
Br J Anaesth. 1984 May;56(5):437-45. doi: 10.1093/bja/56.5.437.
The theory, that the decrease in lung volume which occurs after induction of general anaesthesia is the cause of the higher (PAO2-PaO2) during anaesthesia, was examined in 18 patients. Lung volume was increased during anaesthesia by changing the posture of the patient to 30 degrees head-up, but there was no improvement in (PAO2-PaO2). There were no correlations between change in (PAO2-PaO2) and in cardiac output between different postures. It is concluded that gas exchange is independent of change in lung volume during anaesthesia, at least over the range examined. It remains possible that restoration of lung volume to pre-anaesthetic values may not restore regional distribution of ventilation to pre-anaesthetic values.
在18名患者中对以下理论进行了研究：全身麻醉诱导后肺容量降低是麻醉期间（动脉血氧分压 - 动脉血氧含量差）[PAO2 - PaO2]升高的原因。通过将患者体位改为头高位30度，在麻醉期间增加肺容量，但（PAO2 - PaO2）并无改善。不同体位之间（PAO2 - PaO2）的变化与心输出量的变化之间没有相关性。得出的结论是，至少在所研究的范围内，麻醉期间气体交换与肺容量变化无关。肺容量恢复到麻醉前的值仍有可能无法使通气的区域分布恢复到麻醉前的值。
