Mannering D, Bennett E D, Mehta N, Kemp F
Br J Clin Pharmacol. 1984 Apr;17(4):373-8. doi: 10.1111/j.1365-2125.1984.tb02360.x.
The peripheral haemodynamic effects of a 40 mg intravenous injection of domperidone (a dopamine antagonist) have been studied in 10 normal subjects. In four subjects domperidone was infused directly into the brachial artery and the effects on forearm blood flow were measured. When administered systemically, domperidone significantly decreased forearm blood flow by 9% (P less than 0.01) and significantly increased calculated forearm vascular resistance by 11% (P less than 0.01). The drug produced no measurable changes in forearm blood flow at any dose when infused directly into the brachial artery. A further study was carried out into the effects of a systemic injection of domperidone on peripheral sympathetic tone. Reduction of sympathetic tone in the forearm was achieved by passively raising the legs of eight recumbent subjects. Before domperidone administration, passive leg elevation significantly increased forearm blood flow by 39% and decreased forearm vascular resistance by 13%. After drug administration the absolute values of vascular resistance increased and the changes between the supine and elevated position values when compared with those of the corresponding values prior to drug administration were significantly lower. These results suggest that the role of domperidone in increasing peripheral vascular tone is unlikely to be mediated by a direct local effect on peripheral resistance vessels. Any effect the drug may have is suggested to be mediated via a central control mechanism.
已在10名正常受试者中研究了静脉注射40毫克多潘立酮（一种多巴胺拮抗剂）的外周血流动力学效应。在4名受试者中，将多潘立酮直接注入肱动脉，并测量其对前臂血流量的影响。全身给药时，多潘立酮使前臂血流量显著降低9%（P<0.01），并使计算得出的前臂血管阻力显著增加11%（P<0.01）。当直接注入肱动脉时，该药物在任何剂量下均未引起前臂血流量的可测量变化。进一步研究了全身注射多潘立酮对外周交感神经张力的影响。通过被动抬高8名卧位受试者的腿部来降低前臂的交感神经张力。在给予多潘立酮之前，被动抬腿使前臂血流量显著增加39%，前臂血管阻力降低13%。给药后，血管阻力的绝对值增加，与给药前相应值相比，仰卧位和抬高位置值之间的变化显著降低。这些结果表明，多潘立酮增加外周血管张力的作用不太可能通过对外周阻力血管的直接局部作用来介导。该药物可能产生的任何作用都提示是通过中枢控制机制介导的。
