Ziegler M G, Lake C R, Williams A C, Teychenne P F, Shoulson I, Steinsland O
Clin Pharmacol Ther. 1979 Feb;25(2):137-42. doi: 10.1002/cpt1979252137.
Bromocriptine is a dopamine agonist that induces postural hypotension and can be used as an antihypertensive. The drug inhibits release of norepinephrine (NE) from an isolated artery by stimulating presynaptic receptors. In normotensive subjects it lowers both plasma and cerebrospinal fluid (CSF) levels of NE by 50% and lowers blood pressure moderately in standing subjects and slightly in recumbent subjects. Through central and peripheral mechanisms, bromocriptine inhibits sympathetic nervous discharge of NE.
溴隐亭是一种多巴胺激动剂，可引起体位性低血压，可用作抗高血压药。该药物通过刺激突触前受体抑制离体动脉去甲肾上腺素（NE）的释放。在血压正常的受试者中，它可使血浆和脑脊液（CSF）中的NE水平均降低50%，使站立受试者的血压适度降低，使卧位受试者的血压轻度降低。通过中枢和外周机制，溴隐亭抑制NE的交感神经释放。
