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High-mannose oligosaccharides from human Tamm-Horsfall glycoprotein.

作者信息

Serafini-Cessi F, Dall'Olio F, Malagolini N

出版信息

Biosci Rep. 1984 Mar;4(3):269-74. doi: 10.1007/BF01119663.

DOI:10.1007/BF01119663
PMID:6722291
Abstract

The present communication reports the occurrence of high-mannose oligosaccharides on Tamm-Horsfall glycoprotein prepared from human pooled urine. The Pronase digest of the glycoprotein was fractionated by gel filtration and a high-mannose glycopeptide species was separated from complex-type glycopeptides. When high-mannose glycopeptides were digested with endo-beta-N-acetylglucosaminidase H, followed by reduction with [3H]KBH4, three oligosaccharides were resolved by thin-layer chromatography. On the basis of chromatographic mobility and exoglycosidase digestions the composition Man7-, Man6-, and Man5-GlcNAc was assigned to the three oligosaccharides. Man6GlcNAc is by far the major component.

摘要

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