Hartveit F, Thoresen S, Maehle B O
Br J Surg. 1984 Jun;71(6):463-5. doi: 10.1002/bjs.1800710621.
The range in survival time in operable node-positive breast carcinoma is considerable. Postoperative management is thus dependent on accurate prognostic assessment. This involves the choice of relevant prognostic factors. Theoretically these should include measurements of both stage and growth rate. In a series of 96 cases it is demonstrated that the diameter of the primary (3 cm and under/over 3 cm) can be used as a measure of tumour stage; the histological grade of the primary as one of tumour growth rate; and the presence/absence of tumour cells in the efferent nodal vessels (EVI status) as a measure of nodal stage. The latter is proposed as an alternative to the number of tumour-bearing nodes recovered from the axilla. Division of the cases on this basis was sufficient to assess high or low risk using routine histological methods.
可手术的淋巴结阳性乳腺癌患者的生存时间范围差异很大。因此，术后管理依赖于准确的预后评估。这涉及到相关预后因素的选择。理论上，这些因素应包括分期和生长速率的测定。在一组96例病例中表明，原发肿瘤直径（3厘米及以下/超过3厘米）可作为肿瘤分期的一项指标；原发肿瘤的组织学分级作为肿瘤生长速率的指标之一；以及输出淋巴管中肿瘤细胞的有无（EVI状态）作为淋巴结分期的指标。后者被提议作为从腋窝回收的有肿瘤转移淋巴结数量的替代指标。在此基础上对病例进行划分足以使用常规组织学方法评估高风险或低风险。
