Maehle B O, Skjaerven R
Br J Surg. 1984 Jun;71(6):459-62. doi: 10.1002/bjs.1800710620.
This work has identified variables of importance to short- and long-term prognosis in 97 node positive breast cancer patients followed for a minimum of 98 months. The diameter of the primary tumour (less than or equal to 3 cm/greater than 3 cm) is shown to be an important prognostic variable. Its addition to the presence/absence of tumour cells in the efferent nodal vessels and the mean nuclear area of the tumour cells gave correct prediction of the disease outcome, 60 and 98 months after the operation, in 83 and 80 per cent of the patients respectively. Although the number of tumour-bearing nodes is shown to be a strong variable, more information was gained from the tumour diameter. Histological grade was only of value for 5-year prognosis. Factors that did not add information of prognostic value in these circumstances were identified. The proposed models demonstrate the great heterogeneity within this group of patients.
这项研究确定了97例淋巴结阳性乳腺癌患者短期和长期预后的重要变量，这些患者至少随访了98个月。原发肿瘤直径（小于或等于3厘米/大于3厘米）被证明是一个重要的预后变量。将其与输出淋巴结血管中是否存在肿瘤细胞以及肿瘤细胞的平均核面积相结合，分别在术后60个月和98个月对83%和80%的患者的疾病转归做出了正确预测。虽然有肿瘤的淋巴结数量被证明是一个强有力的变量，但从肿瘤直径中获得了更多信息。组织学分级仅对5年预后有价值。确定了在这些情况下不增加预后价值信息的因素。所提出的模型证明了这组患者内部存在很大的异质性。
