Barrington-Ward S J, Kilpatrick I C, Phillipson O T, Pycock C J
Brain Res. 1984 May 7;299(1):146-51. doi: 10.1016/0006-8993(84)90797-2.
Controversy surrounds the question as to whether some fibres of the thalamostriatal projection, are cholinergic. The present experiments show that lesions of the parafascicular-intralaminar thalamus produced no reductions in choline acetyltransferase (ChAT) activities in any area of microdissected rat caudate-putamen complex or dorsolateral frontal cortex. We conclude that thalamostriatal projections are entirely non-cholinergic. Furthermore, lesions of the mediodorsal or periventricular thalamus resulted in no change in ChAT activities in their terminal projection areas (medio-/orbitofrontal cortices and nucleus accumbens, respectively). The probability that all thalamic outputs are non-cholinergic is discussed.
围绕丘脑纹状体投射的某些纤维是否为胆碱能纤维这一问题存在争议。目前的实验表明，束旁核 - 板内核丘脑损伤并未使显微解剖的大鼠尾状核 - 壳核复合体或背外侧额叶皮质的任何区域的胆碱乙酰转移酶（ChAT）活性降低。我们得出结论，丘脑纹状体投射完全是非胆碱能的。此外，背内侧丘脑或室周丘脑损伤并未导致其终末投射区域（分别为内侧/眶额叶皮质和伏隔核）的ChAT活性发生变化。本文讨论了所有丘脑输出均为非胆碱能的可能性。
