Berendse H W, Groenewegen H J
Department of Anatomy and Embryology, Vrije Universiteit, Amsterdam, The Netherlands.
J Comp Neurol. 1990 Sep 8;299(2):187-228. doi: 10.1002/cne.902990206.
The organization of the thalamic projections to the ventral striatum in the rat was studied by placing injections of the retrograde tracer cholera toxin subunit B in the ventral striatum and small deposits of the anterograde tracer Phaseolus vulgaris-leucoagglutinin (PHA-L) in individual midline and intralaminar thalamic nuclei. In order to provide a complete map of the midline and intralaminar thalamostriatal projections, PHA-L injections were also made in those parts of the intralaminar nuclei that project to the dorsal striatum. The relationship of thalamic afferent fibres with the compartmental organization of the ventral striatum was assessed by combining PHA-L tracing and enkephalin immunohistochemistry. The various midline and intralaminar thalamic nuclei project to longitudinally oriented striatal sectors. The paraventricular thalamic nucleus sends most of its fibres to medial parts of the nucleus accumbens and the olfactory tubercle, whereas smaller contingents of fibres terminate in the lateral part of the nucleus accumbens and the most ventral, medial, and caudal parts of the caudate-putamen complex. The projections of the parataenial nucleus are directed towards central and ventral parts of the nucleus accumbens and intermediate mediolateral parts of the olfactory tubercle. The intermediodorsal nucleus projects to lateral parts of the nucleus accumbens and the olfactory tubercle and to ventral parts of the caudate-putamen. The projection of the rhomboid nucleus is restricted to the rostrolateral extreme of the striatum. A diffuse projection to the ventral striatum arises from neurons ventral and caudal to the nucleus reuniens rather than from cells inside the nucleus. Fibres from the central medial nucleus terminate centrally and dorsolaterally in the rostral part of the nucleus accumbens and medially in the caudate-putamen. Successively more lateral positions in the caudate-putamen are occupied by fibres from the paracentral and central lateral nuclei, respectively. The lateral part of the parafascicular nucleus projects to the most lateral part of the caudate-putamen, whereas projections from the medial part of this nucleus terminate in the medial part of the caudate-putamen and in the dorsolateral part of the nucleus accumbens. Furthermore, a rostral to caudal gradient in a midline or intralaminar nucleus corresponds to a dorsal to ventral and rostral to caudal gradient in the striatum. In the ventral striatum, thalamic afferent fibres in the "shell" region of the nucleus accumbens avoid areas of high cell density and weak enkephalin immunoreactivity.(ABSTRACT TRUNCATED AT 400 WORDS)
通过将逆行示踪剂霍乱毒素B亚单位注射到腹侧纹状体，并将顺行示踪剂菜豆白细胞凝集素（PHA-L）的小剂量沉积物注射到单个中线和板内核丘脑核中，研究了大鼠丘脑向腹侧纹状体的投射组织。为了提供中线和板内核丘脑纹状体投射的完整图谱，还在投射到背侧纹状体的板内核部分进行了PHA-L注射。通过结合PHA-L追踪和脑啡肽免疫组织化学来评估丘脑传入纤维与腹侧纹状体分区组织的关系。各种中线和板内核丘脑核投射到纵向排列的纹状体区域。室旁丘脑核将其大部分纤维发送到伏隔核的内侧部分和嗅结节，而较小部分的纤维终止于伏隔核的外侧部分以及尾壳核复合体最腹侧、内侧和尾侧部分。旁室核的投射指向伏隔核的中央和腹侧部分以及嗅结节的中间中外侧部分。背内侧核投射到伏隔核和嗅结节的外侧部分以及尾壳核的腹侧部分。菱形核的投射仅限于纹状体的 rostrolateral 极端。向腹侧纹状体的弥散投射起源于 reunens 核腹侧和尾侧的神经元，而不是来自核内的细胞。中央内侧核的纤维在伏隔核的前部中央和背外侧以及尾壳核的内侧终止。尾壳核中依次更外侧的位置分别被来自中央旁核和中央外侧核的纤维占据。束旁核的外侧部分投射到尾壳核的最外侧部分，而该核内侧部分的投射终止于尾壳核的内侧部分和伏隔核的背外侧部分。此外，中线或板内核中的头端到尾端梯度对应于纹状体中的背侧到腹侧以及头端到尾端梯度。在腹侧纹状体中，伏隔核“壳”区域的丘脑传入纤维避开细胞密度高和脑啡肽免疫反应弱的区域。（摘要截断于400字）
