Gerad H, van Echo D A, Whitacre M, Ashman M, Helrich M, Foy J, Ostrow S, Wiernik P H, Aisner J
Cancer. 1984 Jun 15;53(12):2585-91. doi: 10.1002/1097-0142(19840615)53:12<2585::aid-cncr2820531203>3.0.co;2-2.
Eleven patients with advanced soft tissue sarcoma were treated with whole body hyperthermia (41.8 degrees C-43.0 degrees C) for 2 hours, doxorubicin (45 mg/m2) at the beginning of peak temperature and cyclophosphamide (1000 mg/m2) 6 hours after doxorubicin. Warming was accomplished with a nylon and vinyl mesh water perfused suit and heating blankets under barbiturate anesthesia. Thirty-five thermochemotherapy treatments were administered after an initial baseline euthermic course. There were two complete and two partial responses including three of three liposarcomas and one of two leiomyosarcomas, and there were two disease stabilizations . Morbidity included anasarca, nausea and vomiting, diarrhea, myalgias, mild surface burns, perioral herpes simplex, reversible neuropathy, hypotension, and cardiac arrythmias . Hyperglycemia and hypophosphatemia were found during heating, and normalized at 24 hours. Liver enzyme elevations occurred 24 hours after heating and normalized within 1 week. A uniform platelet decrease (mean, 107,000/microliter) was found at 24 hours. Thermochemotherapy was found to be a feasible approach for selected patients with advanced soft tissue sarcoma for the subset of liposarcomas and leiomyosarcomas.
11例晚期软组织肉瘤患者接受了全身热疗（41.8摄氏度至43.0摄氏度）2小时，在体温峰值开始时给予阿霉素（45mg/m²），在阿霉素给药6小时后给予环磷酰胺（1000mg/m²）。在巴比妥类麻醉下，使用尼龙和乙烯基网状水灌注服及加热毯进行升温。在初始基线正常体温疗程后进行了35次热化疗治疗。有2例完全缓解和2例部分缓解，包括3例脂肪肉瘤中的3例和2例平滑肌肉瘤中的1例，还有2例病情稳定。不良反应包括全身性水肿、恶心呕吐、腹泻、肌痛、轻度体表烧伤、口腔单纯疱疹、可逆性神经病变、低血压和心律失常。加热期间发现高血糖和低磷血症，并在24小时内恢复正常。加热后24小时出现肝酶升高，并在1周内恢复正常。在24小时时发现血小板均匀下降（平均为107,000/微升）。热化疗被发现是一种针对选定的晚期软组织肉瘤患者中脂肪肉瘤和平滑肌肉瘤亚组的可行方法。
