患有和未患子宫内膜癌的绝经后女性的硫酸雌酮血浆水平。

Estrone sulphate plasma levels in postmenopausal women with and without endometrial cancer.

作者信息

Jasonni V M, Bulletti C, Franceschetti F, Bonavia M, Bolelli G, Ciotti P, Flamigni C

出版信息

Cancer. 1984 Jun 15;53(12):2698-700. doi: 10.1002/1097-0142(19840615)53:12<2698::aid-cncr2820531223>3.0.co;2-o.

DOI:10.1002/1097-0142(19840615)53:12<2698::aid-cncr2820531223>3.0.co;2-o

Abstract

Plasma estrone sulphate ( E1S ) and estrone (E1) concentrations were determined in healthy postmenopausal women and in postmenopausal women with endometrial cancer, matched for body weight, age, and years since menopause. E1S levels (mean +/- SD) were significantly higher (P less than 0.05) in cancer patients with normal weight (511 +/- 200 pg/ml) than in control subjects (303 +/- 99 pg/ml). E1S levels were also higher in obese cancer patients (691 +/- 328 pg/ml) than in obese control subjects (610 +/- 139 pg/ml). Both cancer groups showed similar plasma E1 levels as compared with their respective controls. The E1S /E1 ratio was higher in both groups of cancer patients than in control subjects. These data suggest that estrogen conjugates should be taken into account during studies on estrogen balance and endometrial cancer.

摘要

测定了体重、年龄和绝经年限相匹配的健康绝经后妇女及绝经后子宫内膜癌妇女的血浆硫酸雌酮（E1S）和雌酮（E1）浓度。体重正常的癌症患者的E1S水平（均值±标准差）（511±200 pg/ml）显著高于对照组（303±99 pg/ml）（P<0.05）。肥胖癌症患者的E1S水平（691±328 pg/ml）也高于肥胖对照组（610±139 pg/ml）。与各自的对照组相比，两个癌症组的血浆E1水平相似。两组癌症患者的E1S/E1比值均高于对照组。这些数据表明，在雌激素平衡与子宫内膜癌的研究中应考虑雌激素结合物。