布卢姆综合征：正常细胞对姐妹染色单体交换率的体外校正
Bloom's syndrome: in vitro correction of the sister chromatid exchange rate by normal cells.
作者信息
Leroux D, Chmara D, Jalbert P
出版信息
Cancer Genet Cytogenet. 1984 Jun;12(2):139-43. doi: 10.1016/0165-4608(84)90125-0.
PMID:6722755
Abstract
A significant decrease of sister chromatid exchange (SCE) frequencies was observed in Bloom's syndrome(BS) fibroblasts by cocultivation with normal fibroblasts at 5:1, 1:1, 1:5 ratios, and by culture in medium previously used to support normal fibroblasts. On the other hand, the SCE rate of normal fibroblasts was not modified. These results are compared with those from other studies and discussed.
摘要
通过以5:1、1:1、1:5的比例与正常成纤维细胞共培养，以及在先前用于支持正常成纤维细胞的培养基中培养，发现布卢姆综合征（BS）成纤维细胞中的姐妹染色单体交换（SCE）频率显著降低。另一方面，正常成纤维细胞的SCE率未发生改变。将这些结果与其他研究的结果进行了比较并进行了讨论。
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