Ved Brat S, Verma R S, Dosik H
Cancer Genet Cytogenet. 1984 Jul;12(3):267-74. doi: 10.1016/0165-4608(84)90039-6.
Chromosomal aberrations in skin fibroblasts from Bloom's syndrome cell line GM 1492 are described. As expected, the sister chromatid exchange (SCE) frequency was high. Four very common chromosomal rearrangements included dup( 6q ), t(13;15), dic(16), and del(11q). The nucleolar organizer regions (NOR) in the dicentric t(13;15) were active. The increased incidence of chromosomal markers suggests an evolution of clones in the cell line.
描述了来自布卢姆综合征细胞系GM 1492的皮肤成纤维细胞中的染色体畸变。正如预期的那样，姐妹染色单体交换（SCE）频率很高。四种非常常见的染色体重排包括dup(6q)、t(13;15)、dic(16)和del(11q)。双着丝粒t(13;15)中的核仁组织区（NOR）是活跃的。染色体标记发生率的增加表明该细胞系中克隆的演变。
