Dabeva M D, Dineva B B, Ikonomova R N
Cell Biol Int Rep. 1984 Mar;8(3):231-7. doi: 10.1016/0309-1651(84)90036-5.
The ribosome formation in four experimental groups: normal, adrenalectomized, partially hepatectomized and adrenalectomized - partially hepatectomized rats was studied. Ribosomal RNA was labelled for different intervals and the transfer of the radioactivity from 45 S pre-rRNA through the nucleolar pre-rRNA and rRNA pools into cytoplasmic 28S and 18S rRNA was followed. The results show that there are at least two ways of positive control of rRNA synthesis, one of them being glucocorticoid-dependent. The acceleration of the pre-rRNA processing through the shortest maturation pathway in regenerating liver is reduced in the absence of the hormone. Glucocorticoids do not influence nucleo-cytoplasmic rRNA transport.
对四组实验大鼠（正常、肾上腺切除、部分肝切除以及肾上腺切除 - 部分肝切除大鼠）的核糖体形成进行了研究。核糖体RNA在不同时间段被标记，然后追踪放射性从45S前体rRNA通过核仁前体rRNA和rRNA库转移到细胞质28S和18S rRNA中的情况。结果表明，rRNA合成至少有两种正调控方式，其中一种依赖糖皮质激素。在缺乏该激素的情况下，再生肝中通过最短成熟途径进行的前体rRNA加工加速过程会减弱。糖皮质激素不影响核质rRNA转运。
