Abdel-Halim M N
Int J Radiat Biol Relat Stud Phys Chem Med. 1977 May;31(5):459-65. doi: 10.1080/09553007714550551.
The effect of whole-body irradiation on RNA synthesis in regenerating and non-growing livers was studied in intact and adrenalectomized rats. The animals were divided into four sub-groups: (1) control; (2) irradiation only; (3) partially-hepatectomized; and (4) irradiated partially-hepatectomized. Newly-synthesized RNA was determined by 30 or 40 min uptake of (6-14C) orotic acid. Both nuclear and polyribosomal RNA synthesis in regenerating livers of adrenalectomized rats were depressed below their control levels, regardless of whether irradiation was 2 hours before or 2 hours after partial hepatectomy. Specific radioactivity values of regenerating livers of adrenal intact and adrenalectomized rats were elevated above those of the non-growing livers from irradiated and unirradiated rats.
在完整和肾上腺切除的大鼠中研究了全身照射对再生肝和非生长肝中RNA合成的影响。动物被分为四个亚组：(1)对照组；(2)仅照射组；(3)部分肝切除组；(4)照射后部分肝切除组。通过(6-14C)乳清酸摄取30或40分钟来测定新合成的RNA。无论全身照射是在部分肝切除前2小时还是后2小时进行，肾上腺切除大鼠再生肝中的核RNA和多核糖体RNA合成均低于其对照水平。肾上腺完整和肾上腺切除大鼠再生肝的比放射性值高于照射和未照射大鼠非生长肝的比放射性值。
