Gracey D R, Howard F M, Divertie M B
Chest. 1984 Jun;85(6):739-43. doi: 10.1378/chest.85.6.739.
During a 42-month period, we used plasmapheresis to treat four cases of myasthenia gravis with refractory respiratory failure. All four patients were ventilator dependent for prolonged periods and were not responding to management with cholinesterase inhibitors and corticosteroids. All four patients rapidly responded to the plasmapheresis; respiratory muscle strength returned sufficiently to allow discontinuation of assisted mechanical ventilation and removal of the artificial airway. In our experience, plasmapheresis is indicated in the treatment of the myasthenia gravis patient with respiratory failure which is refractory to conventional drug therapy.
在42个月的时间里，我们使用血浆置换术治疗了4例伴有难治性呼吸衰竭的重症肌无力患者。所有4例患者长期依赖呼吸机，对胆碱酯酶抑制剂和皮质类固醇治疗均无反应。所有4例患者对血浆置换术均迅速产生反应；呼吸肌力量恢复到足以停用辅助机械通气并拔除人工气道的程度。根据我们的经验，血浆置换术适用于治疗对传统药物治疗无效的伴有呼吸衰竭的重症肌无力患者。
