Straus S E, Seidlin M, Takiff H
Drugs. 1984 Apr;27(4):364-72. doi: 10.2165/00003495-198427040-00004.
Herpes simplex virus type 1 and 2 are causes of common inflammatory conditions of the mucous membranes and skin. The proper management of these infections begins with an accurate diagnosis. Viral cultures should be performed whenever possible. Patients should be counselled regarding the proper care of lesions, the risk of complications, the likelihood of experiencing recurrent infection, and should be urged to avoid intimate contact while lesions are active. Antiviral therapy is now available to ameliorate the symptoms and shorten the duration of infection in selected patients, but does not prevent recurrences. Topical, oral and intravenous preparations of acyclovir are effective in treatment of primary herpes simplex infections. Immunosuppressed patients with herpes simplex infections also benefit from acyclovir therapy. Oral activity has some activity in ameliorating recurrent genital herpes and should be considered for patients who are particularly troubled by their infections.
1型和2型单纯疱疹病毒是引起黏膜和皮肤常见炎症的病因。这些感染的恰当处理始于准确诊断。只要有可能，就应进行病毒培养。应向患者提供有关皮损的正确护理、并发症风险、复发感染可能性的咨询，并应敦促患者在皮损活跃时避免密切接触。现在有抗病毒疗法可改善选定患者的症状并缩短感染持续时间，但不能预防复发。阿昔洛韦的局部、口服和静脉制剂对原发性单纯疱疹感染有效。患有单纯疱疹感染的免疫抑制患者也可从阿昔洛韦治疗中获益。口服制剂在改善复发性生殖器疱疹方面有一定作用，对于受感染困扰特别严重的患者应考虑使用。
