一种能区分结合型和游离型人分泌成分的单克隆抗体。
A monoclonal antibody which differentiates between bound and free human secretory component.
作者信息
Gore M E, Bunnage H J, McIlhinney R A
出版信息
Eur J Immunol. 1984 Apr;14(4):344-9. doi: 10.1002/eji.1830140413.
PMID:6723771
Abstract
In this study a mouse monoclonal antibody ( LICR -LON- LC28 ) to human secretory component (SC) is reported. This antibody binds to free SC or to SC associated with IgA or IgM. It exhibits a 10-fold higher affinity for SC bound to IgA than for free SC. The affinity of the antibody for SC associated with IgM is equivalent to that seen for free SC. LICR -LON- LC28 appears to be species specific and does not cross-react with other human milk proteins.
摘要
本研究报道了一种针对人分泌成分（SC）的小鼠单克隆抗体（LICR-LON-LC28）。该抗体可与游离的SC或与IgA或IgM相关的SC结合。它对与IgA结合的SC的亲和力比对游离SC的亲和力高10倍。该抗体对与IgM相关的SC的亲和力与对游离SC的亲和力相当。LICR-LON-LC28似乎具有种属特异性，不与其他母乳蛋白发生交叉反应。
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