Abel F L
Eur J Pharmacol. 1984 Mar 2;98(3-4):367-79. doi: 10.1016/0014-2999(84)90285-1.
The direct effects of norepinephrine, epinephrine, isoproterenol, aminophylline, dopamine and papaverine on coronary blood flow and oxygen consumption were examined in an isolated heart-lung preparation. Only papaverine and aminophylline significantly increased coronary blood flow, although microsphere studies indicated the increase in flow did not primarily involve the endocardial layer. Fractionation of flow into systolic and diastolic components also suggested that both drugs dilated large epicardial vessels. Correlation analysis indicated that alterations in heart rate and performance indices produced by these agents were not per se accompanied by changes in oxygen consumption and/or coronary flow as commonly supposed. Only cardiac work and ejection velocity were directly correlated with oxygen consumption, probably by direct action of the drug on coronary vascular resistance rather than on ventricular function.
在离体心肺制备中研究了去甲肾上腺素、肾上腺素、异丙肾上腺素、氨茶碱、多巴胺和罂粟碱对冠状动脉血流量和氧耗的直接影响。只有罂粟碱和氨茶碱能显著增加冠状动脉血流量，尽管微球研究表明血流量增加主要不涉及心内膜层。将血流量分为收缩期和舒张期成分的分析也表明，这两种药物都能扩张大的心外膜血管。相关性分析表明，这些药物引起的心率和性能指标的改变本身并不像通常所认为的那样伴随着氧耗和/或冠状动脉血流量的变化。只有心脏作功和射血速度与氧耗直接相关，这可能是由于药物对冠状动脉血管阻力的直接作用，而不是对心室功能的作用。
