氨茶碱前后冠状动脉对缺氧的血管舒张反应。
Coronary vasodilator responses to hypoxia before and after aminophylline.
作者信息
Afonso S, Ansfield T J, Berndt T B, Rowe G G
出版信息
J Physiol. 1972 Mar;221(3):589-99. doi: 10.1113/jphysiol.1972.sp009769.
Abstract
- In previous studies adenosine has been postulated to be the mediator in coronary blood flow regulation and aminophylline was found to inhibit the coronary vasodilator action of adenosine. The present study was performed to determine whether aminophylline inhibits coronary vasodilatation induced by hypoxia.2. Coronary and systemic haemodynamic and metabolic effects of hypoxia were studied in anaesthetized dogs before and after aminophylline. Aminophylline did not influence coronary vasodilatation induced by hypoxia.3. These results are held not to lend support to the hypothesis that adenosine is the metabolite responsible for the regulation of coronary blood flow.
摘要
- 在以往的研究中，腺苷被假定为冠状动脉血流调节中的介质，并且发现氨茶碱可抑制腺苷的冠状动脉舒张作用。本研究旨在确定氨茶碱是否抑制缺氧诱导的冠状动脉舒张。2. 在氨茶碱给药前后，对麻醉犬缺氧的冠状动脉和全身血流动力学及代谢效应进行了研究。氨茶碱不影响缺氧诱导的冠状动脉舒张。3. 这些结果不支持腺苷是负责调节冠状动脉血流的代谢产物这一假说。
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