Duncan R, McConkey E H
Exp Cell Res. 1984 Jun;152(2):520-7. doi: 10.1016/0014-4827(84)90654-2.
Dichlororibofuranosyl benzimidazole (DRB), a potent inhibitor of nuclear RNA synthesis and messenger RNA (mRNA) accumulation, produces a paradoxical mobilization of rRNA and mRNA from the subpolysomal pool into polysomes in HeLa cells during the first 40 min of treatment. S6 is phosphorylated concurrently with polysome accumulation, and ribosomal subunits containing phosphorylated S6 are preferentially localized in polysomes, indicating that they form initiation complexes more readily than their non-phosphorylated counterparts.
二氯呋喃核糖基苯并咪唑（DRB）是一种有效的核RNA合成和信使RNA（mRNA）积累抑制剂，在处理的前40分钟内，它会使HeLa细胞中核糖体RNA（rRNA）和mRNA从亚多聚核糖体池中反常地转移到多聚核糖体中。S6在多聚核糖体积累的同时发生磷酸化，并且含有磷酸化S6的核糖体亚基优先定位于多聚核糖体中，这表明它们比未磷酸化的对应物更容易形成起始复合物。
