Stiksa G, Nemcek K, Melin S
Eur J Respir Dis. 1984 May;65(4):278-82.
The additional effect of N-acetylcysteine in combination with inhaled terbutaline was studied in a controlled randomized double-blind cross-over study of one week periods in 22 patients with stable reversible chronic obstructive pulmonary disease. The patients improved clinically, more during the period with acetylcysteine in combination with terbutaline, than during the period with placebo/terbutaline. The differences were particularly noticeable on the parameters 'difficulties in raising sputum' and 'number of coughs'. Seventeen of 22 patients felt greater improvement during the period with acetylcysteine. Also a small improvement in FEV1 was found by addition of acetylcysteine. No side-effects of acetylcysteine were reported in this combination.
在一项针对22例稳定期可逆性慢性阻塞性肺疾病患者的对照随机双盲交叉研究中，研究了N-乙酰半胱氨酸联合吸入特布他林的附加效果。患者的临床症状有改善，在使用乙酰半胱氨酸联合特布他林的期间比使用安慰剂/特布他林的期间改善更明显。在“咳痰困难”和“咳嗽次数”参数上差异尤为显著。22例患者中有17例在使用乙酰半胱氨酸期间感觉改善更明显。添加乙酰半胱氨酸后，第一秒用力呼气容积（FEV1）也有小幅改善。该联合用药未报告乙酰半胱氨酸的副作用。
