糖皮质激素诱导的后肾发育异常的新模型。
A new model of glucocorticoid-induced metanephric maldevelopment.
作者信息
Avner E D, Sweeney W E, Piesco N P, Ellis D
出版信息
Experientia. 1984 May 15;40(5):489-90. doi: 10.1007/BF01952400.
PMID:6723915
Abstract
A new experimental model of glucocorticoid-induced tubular cyst formation has been developed in metanephric organ culture. The addition of cortisol (1.4 X 10(-5) M) to chemically defined serum-free culture medium produces cystic changes during in vitro nephrogenesis . The model isolates the role of glucocorticoids in experimental cyst formation.
摘要
在肾元器官培养中已建立了一种新的糖皮质激素诱导肾小管囊肿形成的实验模型。在化学成分明确的无血清培养基中添加皮质醇（1.4×10⁻⁵ M）会在体外肾发生过程中产生囊性变化。该模型分离出了糖皮质激素在实验性囊肿形成中的作用。
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