抗肝脏和莫里斯肝癌7777质膜抗血清的不同黏附抑制活性。
Different adhesion inhibiting activities of antisera against plasma membranes of liver and Morris hepatoma 7777.
作者信息
Neumeier R, Dethlefs U, Reutter W
出版信息
FEBS Lett. 1984 Mar 26;168(2):241-4. doi: 10.1016/0014-5793(84)80254-9.
Cell-substratum adhesion of rat hepatocytes was inhibited by antisera raised against plasma membranes of liver (anti-liver antiserum) and Morris hepatoma 7777 (anti-hepatoma antiserum). Similar concentrations of both antisera inhibited adhesion on collagen. Anti-liver antiserum also inhibited the adhesion of hepatocytes on plastic, whereas anti-hepatoma antiserum was only able to inhibit the adhesion on collagen completely. These results suggest the existence of at least two different adhesion-involved molecules. Cells adhere to plastic by means of both molecules, whereas adhesion on collagen is mediated by only one of them. The results further suggest that hepatoma cells lost the molecule involved in adhesion on plastic.
用针对肝脏质膜产生的抗血清（抗肝脏抗血清）和莫里斯肝癌7777的抗血清（抗肝癌抗血清）可抑制大鼠肝细胞与基质的黏附。两种抗血清的相似浓度均可抑制在胶原蛋白上的黏附。抗肝脏抗血清还可抑制肝细胞在塑料上的黏附，而抗肝癌抗血清仅能完全抑制在胶原蛋白上的黏附。这些结果表明至少存在两种不同的参与黏附的分子。细胞通过这两种分子黏附于塑料，而在胶原蛋白上的黏附仅由其中一种分子介导。结果还表明肝癌细胞失去了参与在塑料上黏附的分子。
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