伴刀豆球蛋白A、触珠蛋白和胰蛋白酶之间的结构相似性。

Structural similarities among concanavalin A, haptoglobin, and trypsin.

作者信息

Dobryszycka W, Przysiecki B

出版信息

FEBS Lett. 1984 Jun 4;171(1):85-8. doi: 10.1016/0014-5793(84)80464-0.

Abstract

Comparison of the primary structure of concanavalin A with those of trypsin and beta (heavy) chain of haptoglobin revealed a significant degree of chemical similarity. The amino acid sequence of concanavalin A was found to be 53.6% related to trypsin and haptoglobin. Certain analogy in the tertiary structure was shown by the use of thionine binding to the specific active site, characteristic for serine proteases.

摘要

伴刀豆球蛋白A的一级结构与胰蛋白酶和触珠蛋白的β（重）链的一级结构相比较，显示出显著程度的化学相似性。发现伴刀豆球蛋白A的氨基酸序列与胰蛋白酶和触珠蛋白有53.6%的相关性。通过使用硫堇结合到丝氨酸蛋白酶特有的特定活性位点，显示出三级结构上的某些相似性。