Letnansky K
FEBS Lett. 1984 Jun 4;171(1):9-12. doi: 10.1016/0014-5793(84)80450-0.
A polypeptide isolated from the maternal part of bovine placentas inhibits significantly the incorporation of thymidine into the DNA of tumor cells. When normal cells are used, this effect is found only to a very limited degree. Surface membrane components have been identified which are enriched on tumor cells and which are responsible for a better binding of the inhibitor to tumor cells than to normal cells. After internalization of the receptor-inhibitor complex, a decrease in the nuclear content of two proteins is observed, which might be a requirement for the inhibition of the DNA synthesis.
从牛胎盘母体部分分离出的一种多肽能显著抑制胸苷掺入肿瘤细胞的DNA。当使用正常细胞时，这种作用仅在非常有限的程度上被发现。已鉴定出肿瘤细胞表面富集的膜成分，正是这些成分使得抑制剂与肿瘤细胞的结合比与正常细胞的结合更好。受体-抑制剂复合物内化后，观察到两种蛋白质的核含量降低，这可能是抑制DNA合成的必要条件。
