用单克隆抗体鉴定催乳素的Mr变体。

Identification of Mr variants of prolactin with monoclonal antibodies.

作者信息

Aston R, Young K, van den Berg H, Ivanyi J

出版信息

FEBS Lett. 1984 Jun 11;171(2):192-6. doi: 10.1016/0014-5793(84)80486-x.

Abstract

Monoclonal antibodies ( QB01 and 1200) prepared against human prolactin (hPRL) have helped define a variant form of the hormone. This variant is of apparently higher molecular mass (26 kDa) than the predominant form of the hormone (24 kDa) and its presence does not appear to be species-restricted. The demonstration of the 26 kDa form of hPRL in fresh pituitary tissue and amniotic fluid suggests it may retain some specific function.

摘要

针对人催乳素（hPRL）制备的单克隆抗体（QB01和1200）有助于确定该激素的一种变体形式。这种变体的分子量（26 kDa）明显高于该激素的主要形式（24 kDa），并且其存在似乎不受物种限制。在新鲜垂体组织和羊水中发现26 kDa形式的hPRL表明它可能保留一些特定功能。