Mortensen H B, Vølund A A
Diabete Metab. 1984 Jan;10(1):18-24.
Hemoglobin A1c (HbA1c) and the blood glucose concentrations were measured in 26 children with newly diagnosed diabetes mellitus from the start of insulin treatment and during the remission and post-remission phases. The results were analysed according to a biokinetic model which describes HbA1c as a function of the preceeding blood glucose level during the lifetime of the erythrocytes. The correlation between HbA1c and blood glucose at the start of treatment improved significantly when the model was modified to accomodate a change in the blood glucose level at the time when the first diabetic symptoms were noticed. The individual HbA1c values measured after 1, 2 and 3 weeks of insulin treatment were compared with values predicted from the biokinetic model and preceeding blood glucose measurements. There was a significant positive correlation between observed and predicted values, and the correlation increased with the length of the observation period. In all children the HbA1c level declined and reached a nadir 10 to 15 weeks after initiation of treatment. A significant negative correlation between the duration of remission and the HbA1c level was observed. It is concluded that the biokinetic model compares favourably with the observed variations in HbA1c and blood glucose levels which occur in newly diagnosed diabetes mellitus during the first weeks of insulin treatment.
对26名新诊断糖尿病患儿从开始胰岛素治疗起，以及在缓解期和缓解后期，测量了糖化血红蛋白（HbA1c）和血糖浓度。根据一个生物动力学模型对结果进行分析，该模型将HbA1c描述为红细胞寿命期间先前血糖水平的函数。当模型经修改以适应首次注意到糖尿病症状时血糖水平的变化时，治疗开始时HbA1c与血糖之间的相关性显著改善。将胰岛素治疗1、2和3周后测得的个体HbA1c值与生物动力学模型预测值及先前的血糖测量值进行比较。观察值与预测值之间存在显著正相关，且相关性随观察期延长而增加。所有患儿的HbA1c水平均下降，并在治疗开始后10至15周达到最低点。观察到缓解期持续时间与HbA1c水平之间存在显著负相关。结论是，生物动力学模型与新诊断糖尿病患儿在胰岛素治疗最初几周内HbA1c和血糖水平的观察变化相比具有优势。
